XUE LAB
Welcome to
Xue Lab @ Peking University
Cancer Evolution and Immune Microenvironment
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Research Focus
Cancer is an ever-evolving multicellular ecosystem, among which different tumor clones compete for survival advantage and dynamically interacted with the surrounding TIME. Our understanding of the tumor ecosystem is still very limited. Detailed investigation of the cooperation of tumor clonal evolution and TIME dynamics is much needed. Our lab is trying to integrate cutting-edge genomics, bioinformatics, and mechanism-based studies to investigate tumor-microenvironment interactions. Our long-term goal is to tackle clinical challenges in early cancer detection, accurate cancer diagnosis and effective treatment.
Recent Work
Gastroenterology 2022
Our work revealed a novel dual-phase copy number evolution model, showed HCC with longer gradual phase was more severe, identified CAD as a promising biomarker for early recurrence of HCC, and supported the diploid origin of polyploid HCC.
Nature 2022
Single-cell RNA-sequencing (scRNA-seq) analysis of 189 samples collected from 124 patients and 8 mice with liver cancer. With more than 1 million cells analysed, we stratified patients into five TIME subtypes called TIMELASER. Our study illustrates diverse TIME subtypes, highlights immunosuppressive functions of TANs and sheds light on potential immunotherapies targeting TANs.
Cancer Cell 2019
Integrative analysis of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes, revealed molecular subtypes, mono- and multiclonal origins of cHCC-ICCs. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC.
Xue Lab is affiliated to
